Risk factors of gestational diabetes mellitus in Wuhan city of China--a case control study

Objective: To explore the main risk factors of gestational diabetes mellitus in Wuhan, China. Methods: 206 women with gestational diabetes mellitus who were diagnosed in Hubei Maternal and Child Health Hospital between January 2014 and December 2015 were selected as case group. Meanwhile, 286 healthy pregnant women, who were delivered at the same time, were selected as control group. Maternal age, occupation, race/ethnicity, gestation status, and family history, etc. were obtained from the face-to-face interviews as well as their medical records. Univariate logistic regression analysis and multivariate logistic regression analysis were conducted to explore the risk factors. Results: The factors included into multivariate logistic regression model were maternal age, menarche age, history of menstrual cycle disorder, spontaneous abortion frequency, maternal history of diabetes, and paternal history of diabetes. The Odds Ratios (95%CI) were 1.50 (1.14~2.04), 0. 36 (0.16~0.84), 3.85 (1. 59~9. 36), 3.00 (1.56~5.77), 3.89 (1.15~13.17) and 6.54 (2.42~17.69), respectively. Conclusion: The risk factors of gestational diabetes mellitus were advanced maternal age, history of menstrual cycle disorder, spontaneous abortion frequency, maternal history of diabetes, and paternal history of diabetes, while advanced menarche age was a protective factor for gestational diabetes mellitus. Correspondence to: Qiong Dai, Department of Child Health Care, Hubei Maternal and Child Health Hospital, Wuhan city, Hubei province, 430070, China, E-mail: [email protected]